A potential cure for baldness may be on the horizon, thanks to groundbreaking baldness research from UCLA. Scientists have developed a new molecule, known as PP405, that has shown early success in stimulating hair regrowth by reactivating dormant hair follicle stem cells. This discovery could revolutionize the treatment of androgenetic alopecia, the most common form of hair loss affecting millions of men and women worldwide.
Targeting the Root Cause of Hair Loss
The research, led by Professors William Lowry, Heather Christofk, and Michael Jung, focuses on the metabolic activity of hair follicle stem cells. These cells are responsible for hair regeneration, but in cases of pattern baldness, they become inactive. The UCLA team found that the production of lactate—a byproduct of glucose metabolism—plays a key role in activating these dormant cells. By increasing lactate levels within the stem cells, hair growth can be stimulated.
From Mice to Molecules: Development of PP405
Two compounds, RCGD423 and UK5099, were used in initial experiments on mice to successfully activate hair follicles. Building on that success, the team developed PP405, a molecule designed for topical use. When applied to the scalps of human participants in early trials, PP405 led to statistically significant hair regrowth, with full, thick terminal hairs rather than the thin, wispy hairs often produced by existing treatments.
Clinical Trials and Future Possibilities
The molecule is now being advanced through clinical trials by Pelage Pharmaceuticals, a biotech company founded by the UCLA researchers. As of August 2024, a Phase 2a trial involving 60 participants is underway to evaluate the safety and effectiveness of PP405 in treating hair loss.
Unlike current FDA-approved options such as minoxidil and finasteride—which come with limitations and side effects—PP405 represents a new class of treatment targeting the root cause of hair follicle inactivity. While additional testing is needed, this scientific breakthrough offers renewed hope to those struggling with hair loss, potentially paving the way for the most effective treatment to date.